Advances in non-covalent based inhibitors targeting Myc: a promising approach for cancer treatment

医学 图书馆学 传统医学 计算机科学
作者
Vipendra Kumar Singh,Naina Rajak,Rajanish Giri,Neha Garg
出处
期刊:Future Medicinal Chemistry [Future Science Ltd]
卷期号:16 (2): 101-103
标识
DOI:10.4155/fmc-2023-0332
摘要

Future Medicinal ChemistryAhead of Print EditorialAdvances in non-covalent based inhibitors targeting Myc: a promising approach for cancer treatmentVipendra Kumar Singh, Naina Rajak, Rajanish Giri & Neha GargVipendra Kumar Singh https://orcid.org/0000-0003-4744-2474School of Biosciences & Bioengineering, Indian Institute of Technology Mandi, VPO Kamand, Mandi-175075, HP, IndiaSearch for more papers by this author, Naina Rajak https://orcid.org/0009-0009-0653-3071Faculty of Ayurveda, Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaSearch for more papers by this author, Rajanish Giri https://orcid.org/0000-0002-2046-836XSchool of Biosciences & Bioengineering, Indian Institute of Technology Mandi, VPO Kamand, Mandi-175075, HP, IndiaSearch for more papers by this author & Neha Garg *Author for correspondence: Tel.: +91 981 808 2907; E-mail Address: nehagarg@bhu.ac.inhttps://orcid.org/0000-0003-2227-8292Faculty of Ayurveda, Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaSearch for more papers by this authorPublished Online:12 Dec 2023https://doi.org/10.4155/fmc-2023-0332AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: cancersMyc proteinnon-covalent inhibitorsoncogeneundruggableReferences1. Ahmadi SE, Rahimi S, Zarandi B, Chegeni R, Safa M. MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies. J. Hematol. Oncol. 14(1), 121 (2021).Crossref, Medline, CAS, Google Scholar2. Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. eBioMedicine 75, 103756 (2022).Crossref, Medline, CAS, Google Scholar3. DePinho R, Mitsock L, Hatton K et al. Myc family of cellular oncogenes. J. Cell. Biochem. 33(4), 257–266 (1987).Crossref, Medline, CAS, Google Scholar4. Chen H, Liu H, Qing G. Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct. Target. Ther. 3(1), 5 (2018).Crossref, Medline, Google Scholar5. Bretones G, Delgado MD, León J. Myc and cell cycle control. Biochim. Biophys. Acta 1849(5), 506–516 (2015).Crossref, Medline, CAS, Google Scholar6. Duffy MJ, O'Grady S, Tang M, Crown J. MYC as a target for cancer treatment. Cancer Treat. Rev. 94, 102154 (2021).Crossref, Medline, CAS, Google Scholar7. Hayward WS, Neel BG, Astrin SM. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290(5806), 475–480 (1981).Crossref, Medline, CAS, Google Scholar8. Madden SK, de Araujo AD, Gerhardt M, Fairlie DP, Mason JM. Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc. Mol. Cancer 20(1), 3 (2021).Crossref, Medline, Google Scholar9. Karadkhelkar NM, Lin M, Eubanks LM, Janda KD. Demystifying the Druggability of the MYC Family of Oncogenes. J. Am. Chem. Soc. 145(6), 3259–3269 (2023).Crossref, Medline, CAS, Google Scholar10. Saeed H, Leibowitz BJ, Zhang L, Yu J. Targeting Myc-driven stress addiction in colorectal cancer. Drug Resist. Updat. 69, 100963 (2023).Crossref, Medline, CAS, Google Scholar11. Adhav VA, Saikrishnan K. The Realm of Unconventional Noncovalent Interactions in Proteins: Their Significance in Structure and Function. ACS Omega 8(25), 22268–22284 (2023).Crossref, Medline, CAS, Google Scholar12. Aljoundi A, Bjij I, El Rashedy A, Soliman MES. Covalent Versus Non-covalent Enzyme Inhibition: Which Route Should We Take? A Justification of the Good and Bad from Molecular Modelling Perspective. Protein J. 39(2), 97–105 (2020).Crossref, Medline, CAS, Google Scholar13. Ross J, Miron CE, Plescia J et al. Targeting MYC: from understanding its biology to drug discovery. Eur. J. Med. Chem. 213, 113137 (2021).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 0 times History Received 10 November 2023 Accepted 27 November 2023 Published online 12 December 2023 Information© 2023 Newlands PressKeywordscancersMyc proteinnon-covalent inhibitorsoncogeneundruggableAuthor contributionsAll authors wrote the manuscript. All authors have given approval to the final version of the manuscript.Financial disclosureThe authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Writing disclosureNo writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
旺仔球完成签到,获得积分10
刚刚
GGY完成签到 ,获得积分10
4秒前
小蘑菇的应助被Tbear采纳,获得10
8秒前
fredxjx完成签到,获得积分10
8秒前
8秒前
阿然完成签到,获得积分10
9秒前
nanjianli完成签到,获得积分10
10秒前
丘比特的应助被多金多金采纳,获得10
12秒前
饕餮完成签到,获得积分10
13秒前
nan发布了新的文献求助10
13秒前
甜蜜的振家完成签到,获得积分10
14秒前
单杨完成签到,获得积分10
14秒前
xuxu125678完成签到 ,获得积分10
15秒前
15秒前
cliff139完成签到,获得积分10
16秒前
论文快来完成签到,获得积分10
16秒前
Inspiring完成签到,获得积分10
17秒前
18秒前
苗条的访冬完成签到 ,获得积分10
19秒前
21秒前
海洋球完成签到,获得积分10
21秒前
21秒前
lucky完成签到,获得积分10
22秒前
WhiteSand完成签到,获得积分10
23秒前
jiangnan发布了新的文献求助30
23秒前
Andrew完成签到 ,获得积分10
24秒前
阿沅完成签到 ,获得积分10
24秒前
24秒前
多金多金发布了新的文献求助10
25秒前
郑浩完成签到,获得积分10
25秒前
TomasLiu完成签到,获得积分10
26秒前
飘飘然会摔死的完成签到 ,获得积分10
26秒前
张淞鑫给张淞鑫的求助进行了留言
26秒前
yesmider完成签到,获得积分10
26秒前
27秒前
立冬完成签到,获得积分10
29秒前
猪猪侠完成签到,获得积分10
29秒前
31秒前
一诺相许完成签到,获得积分10
31秒前
Sarah完成签到 ,获得积分10
31秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
拉伸高分子熔体中缠结行为的模拟和小角中子散射研究 1080
Encyclopedia of Modern Artificial Intelligence 1000
Особенности технологий и методов информационно-психологических войн СССР с Великобританией и США в период 1939-1953 гг 1000
Analyses de reconnaissances de dettes passées devant les échevins d'Ypres (1249-1291) 600
Cellulose and Cellulose Derivatives: Synthesis, Modification and Applications 600
Experimentelle und numerische Modellierung des dynamischen Trag- und Verformungsverhaltens von hochflexiblen Schutzsystemen gegen Steinschlag 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 计算机科学 工程类 有机化学 化学工程 生物化学 物理 复合材料 内科学 催化作用 光电子学 人工智能 细胞生物学 无机化学 物理化学 数学
热门帖子
关注 科研通微信公众号,转发送积分 8147479
求助须知:如何正确求助?哪些是违规求助? 9545613
关于积分的说明 21669831
捐赠科研通 7734190
什么是DOI,文献DOI怎么找? 3423528
关于科研通互助平台的介绍 2548532
邀请新用户注册赠送积分活动 2466496