化学
羟胺
催化作用
亲核细胞
炔烃
钯
氧化还原
羰基化
亲核加成
瓦克过程
组合化学
有机化学
光化学
一氧化碳
作者
Yuanrui Wang,Xiao‐Feng Wu
标识
DOI:10.1016/j.jcat.2023.03.034
摘要
A palladium-catalyzed redox-neutral dicarbonylation of terminal alkynes has been reported, in which hydroxylamine acts as both a nucleophile and a potential oxidant. Maleimides were synthesized in moderate yields under relatively mild conditions while avoiding the addition of equivalent oxidants. This reaction process involves two key steps: the addition of Pd-H to the terminal alkyne, and the hydroxylamine ester intermediate play the role of an internal oxidant via nucleophilic attack by hydroxylamine. This reaction has a wide range of functional group compatibility, and this internal oxidation reaction process also provided a new idea for other oxidative carbonylation reactions.
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