Tyrosine kinase inhibitors-associated interstitial lung disease used in non-small cell lung cancer: a pharmacovigilance analysis based on the FDA adverse event reporting system database

医学 不良事件报告系统 药物警戒 间质性肺病 内科学 不利影响 肺癌 酪氨酸激酶抑制剂 药理学 酪氨酸激酶 安全概况 疾病 重症监护医学 肿瘤科 癌症 受体
作者
Jing Zhang,Ting Qiu,Yiting Zhou,Shengjie Wu,Enguo Chen
出处
期刊:Expert Opinion on Drug Safety [Taylor & Francis]
卷期号:22 (9): 849-856 被引量:5
标识
DOI:10.1080/14740338.2023.2193392
摘要

Background Interstitial lung disease (ILD) was a relatively common cause of drug-induced mortality. However, the safety profile of the whole TKIs induced ILD was largely unknown.Research design and methods The reported cases of ILD associated with TKIs were downloaded from the FDA adverse event reporting system (FAERS) database between 1 January 2004 and 30 April 2022 to detect ILD signals by disproportionality analysis. Furthermore, the fatality rate and time to onset (TTO) of various TKIs were also calculated.Results The median age of total 2999 reported cases was 67. The largest reported cases came from osimertinib (n = 736, 24.5%). However, gefitinib had the highest ROR of 12.47 (11.4, 13.64) and IC of 3.53 (3.23, 3.86), means the strongest association with ILD. Trametinib, vemurafenib, larotectinib, selpercatinib, and cabozantinib did not show ILD signal. The median age of dead cases was 72 (Q1:62, Q3:83), and 53.02% (n = 579) were female and 41.11% (n = 449) were male. MET group showed the highest fatality rate of 55.17% with the shortest median TTO of 21 days (Q1: 8.5, Q3: 35.5).Conclusions TKIs were significantly associated with ILD. More attention should be paid to female, older, MET group with shorter TTO, as their prognosis might be worse.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
呜啦啦完成签到,获得积分10
刚刚
刚刚
lulu8809完成签到,获得积分10
3秒前
3秒前
二十五完成签到,获得积分10
4秒前
romeo完成签到,获得积分10
5秒前
kaka完成签到 ,获得积分10
5秒前
Akim应助xialuoke采纳,获得10
5秒前
昏睡的蟠桃应助guoxingliu采纳,获得200
6秒前
慕容松完成签到,获得积分10
7秒前
romeo发布了新的文献求助10
7秒前
ss_hHe完成签到,获得积分10
8秒前
8秒前
9秒前
zjcomposite完成签到,获得积分10
9秒前
nn发布了新的文献求助10
9秒前
css完成签到,获得积分10
9秒前
大橙子发布了新的文献求助10
10秒前
1111完成签到,获得积分10
10秒前
敏er好学完成签到,获得积分10
11秒前
细腻的谷秋完成签到 ,获得积分10
11秒前
独特的易形完成签到,获得积分10
12秒前
yangyangyang完成签到,获得积分0
15秒前
yirenli完成签到,获得积分10
16秒前
叶子完成签到 ,获得积分10
16秒前
angel完成签到,获得积分10
18秒前
正经大善人完成签到,获得积分10
20秒前
动听的秋白完成签到 ,获得积分10
21秒前
汉堡包应助biofresh采纳,获得30
21秒前
自然归尘完成签到 ,获得积分10
22秒前
缓慢海蓝完成签到 ,获得积分10
24秒前
liyiren完成签到,获得积分10
25秒前
25秒前
zhaopeipei完成签到,获得积分10
25秒前
量子星尘发布了新的文献求助10
26秒前
26秒前
调皮的老王头完成签到,获得积分10
27秒前
毅诚菌完成签到,获得积分10
28秒前
昵称完成签到,获得积分10
30秒前
欸嘿完成签到,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022