亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Transarterial Chemoembolization Combined With Apatinib Plus PD-1 Inhibitors for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Multicenter Retrospective Study

医学 肝细胞癌 阿帕蒂尼 内科学 胃肠病学 放射科 门静脉 多中心研究 血栓 肿瘤科 癌症 随机对照试验
作者
Wei-Li Xia,Xiao-Hui Zhao,Yuan Guo,Hongtao Hu,Guangshao Cao,Zhen Li,Weijun Fan,Shi‐Jun Xu,Hai-Liang Li
出处
期刊:Clinical and translational gastroenterology [Lippincott Williams & Wilkins]
被引量:10
标识
DOI:10.14309/ctg.0000000000000581
摘要

Abstract Purpose: To compare transarterial chemoembolization (TACE) combined with apatinib and PD-1 inhibitor (TACE-AP) with TACE combined with apatinib alone (TACE-A) in the treatment of hepatocellular carcinoma (HCC) with portal tumor thrombus (PVTT) and to explore the prognostic factors affecting the survival of patients. Patients and methods: This retrospective study analyzed data of HCC patients with PVTT who were treated with TACE-AP or TACE-A between January 2018 and June 2021. The primary endpoints of the study were progression-free survival (PFS) and overall survival (OS), and secondary endpoints were objective response rate (ORR) and adverse events (AEs). Propensity score matching (PSM) and inverse probability weighting (IPTW) analysis were used to reduce patient selection bias, and COX regression analysis was used to analyze prognostic factors affecting patient survival. Results: Sixty-nine and 40 patients were included in the TACE-A and TACE-AP group, respectively. After PSM and IPTW analysis, the median PFS and median OS in the TACE-AP group were significantly higher than those in the TACE-A group (PFS: after PSM, 6.9 months vs 4.0 months, P < 0.001, after IPTW, 6.5 months vs 5.1 months, P < 0.001; OS: after PSM,14.6 months vs 8.5 months P < 0.001, after IPTW, 16.1 months vs 10.5 months, P < 0.001). After PSM and IPTW, the tumor ORR in the TACE-AP group was significantly higher than that in the TACE-A group (PSM, 53.6% VS 17.9%, P = 0.005; IPTW, 52.5% vs 28.6%, P = 0.013). All treatment-related adverse reactions (AEs) were observed to be tolerated. Multivariate Cox regression analysis showed that the main prognostic factors affecting the survival of patients were tumor number, PVTT type, AFP, and treatment mode. Conclusion: In the treatment of HCC patients with PVTT, TACE-AP significantly improved PFS, OS and ORR, and the AEs were safe and controllable.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yueying完成签到,获得积分10
4秒前
6秒前
Owen应助尊敬夜南采纳,获得10
9秒前
花凉完成签到,获得积分10
19秒前
花凉发布了新的文献求助20
21秒前
Ava完成签到,获得积分10
26秒前
liudy完成签到,获得积分10
39秒前
Ava发布了新的文献求助50
39秒前
吃了吃了完成签到,获得积分10
40秒前
liudy发布了新的文献求助10
45秒前
领导范儿应助科研通管家采纳,获得10
51秒前
1分钟前
阿紫吖完成签到 ,获得积分10
1分钟前
过时的白曼完成签到,获得积分10
1分钟前
隐形曼青应助三叔采纳,获得10
1分钟前
2分钟前
陈苗发布了新的文献求助10
2分钟前
在水一方应助scholar丨崔采纳,获得10
2分钟前
不能随便完成签到,获得积分10
2分钟前
2分钟前
碧蓝香芦完成签到 ,获得积分10
2分钟前
scholar丨崔发布了新的文献求助10
2分钟前
2分钟前
2分钟前
可爱的函函应助陈苗采纳,获得10
2分钟前
北北完成签到 ,获得积分10
3分钟前
3分钟前
3分钟前
Nowind发布了新的文献求助10
3分钟前
三叔发布了新的文献求助10
3分钟前
三叔完成签到,获得积分0
3分钟前
怕孤单的绿柏完成签到,获得积分10
3分钟前
Augustines完成签到,获得积分10
3分钟前
3分钟前
lijunliang完成签到 ,获得积分10
4分钟前
Lucas应助欣喜的以丹采纳,获得10
4分钟前
爱吃煎饼果子的芋圆完成签到 ,获得积分10
4分钟前
4分钟前
小神仙完成签到 ,获得积分10
4分钟前
尊敬夜南发布了新的文献求助10
4分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990022
求助须知:如何正确求助?哪些是违规求助? 3532092
关于积分的说明 11256327
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805140
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228