芳香化酶
免疫监视
乳腺癌
免疫系统
激素
雌激素受体
雌激素
生物
癌症
肿瘤微环境
肠道菌群
癌症研究
激素疗法
内科学
免疫学
内分泌学
医学
作者
Safae Terrisse,Laurence Zitvogel,Guido Kroemer
出处
期刊:Cell stress
[Shared Science Publishers OG]
日期:2023-03-13
卷期号:7 (3): 12-19
被引量:1
标识
DOI:10.15698/cst2023.03.277
摘要
Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters. Thus, the immunosurveillance system retards the development of hormone-positive breast cancer and contributes to the therapeutic efficacy of estrogen receptor antagonists and aromatase inhibitors. Moreover, the anticancer immune response is profoundly modulated by the local and intestinal microbiota, which influences cancer cell-intrinsic signaling pathways, affects the composition and function of the immune infiltrate present in the tumor microenvironment and modulates the metabolism of estrogens. Indeed, specific bacteria in the gut produce enzymes that affect the enterohepatic cycle of estrogen metabolites, convert estrogens into androgens or generate estrogen-like molecules. The knowledge of these circuitries is in its infancy, calling for further in-depth analyses.
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