医学
内科学
危险系数
骨髓增生异常综合症
比例危险模型
多元分析
单变量分析
肿瘤科
淋巴细胞
临床意义
胃肠病学
置信区间
骨髓
作者
Chuanyang Lu,Qiuni Chen,Jiaxin Li,Chunling Wang,Liang Yu
出处
期刊:Hematology
[Informa]
日期:2023-05-11
卷期号:28 (1)
标识
DOI:10.1080/16078454.2023.2210929
摘要
Previous studies validated the prognostic significance of lymphocyte to monocyte ratio (LMR) in patients with solid tumors and some hematologic malignancies. However, the correlation between LMR and Myelodysplastic Neoplasms (MDS) was unclear. The study intends to investigate the prognostic impact of LMR on MDS patients.91 newly diagnosed MDS patients were included in this retrospective study. The cut-off of LMR was 3.2 by X-Tile. All patients were divided into the low LMR group (<3.2) and the high LMR group (≥3.2). Clinical characteristics were compared between the two groups.Patients in the high LMR group (n = 67) had better OS (P = 0.007) from the Kaplan-Meier survival curves. The results of the univariate analysis demonstrated that LMR was a prognostic factor for OS [hazard ratio (HR) = 2.070, 95%CI 1.201-3.571, P = 0.009]. After multivariate cox analysis, low LMR was confirmed to be an independent predictor of poor OS in MDS patients (HR = 1.872, 95%CI 1.084-3.230, P = 0.024).LMR, a representative marker of systematic inflammation and immune response, has potential prognostic significance in MDS patients.
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