Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein

A series of tau ligands was synthesized replacing the photoisomerisable trans -diene bridge of PBB3 with 1,2,3-triazole, amide, and ester moieties. Several ligands were able to visualise Aβ plaques and neurofibrillary tangles in Alzheimer's disease.