Wearable Localized Surface Plasmon Resonance-Based Biosensor with Highly Sensitive and Direct Detection of Cortisol in Human Sweat

生物传感器 表面等离子共振 材料科学 表面应力 纳米技术 可穿戴计算机 分析物 基质(水族馆) 化学 纳米颗粒 计算机科学 色谱法 生物 嵌入式系统 生态学 表面能 复合材料
作者
Minghui Nan,Bobby Aditya Darmawan,Gwangjun Go,Shirong Zheng,Junhyeok Lee,Seokjae Kim,Taeksu Lee,Eunpyo Choi,Jong-Oh Park,Doyeon Bang
出处
期刊:Biosensors [MDPI AG]
卷期号:13 (2): 184-184
标识
DOI:10.3390/bios13020184
摘要

Wearable biosensors have the potential for developing individualized health evaluation and detection systems owing to their ability to provide continuous real-time physiological data. Among various wearable biosensors, localized surface plasmon resonance (LSPR)-based wearable sensors can be versatile in various practical applications owing to their sensitive interactions with specific analytes. Understanding and analyzing endocrine responses to stress is particularly crucial for evaluating human performance, diagnosing stress-related diseases, and monitoring mental health, as stress takes a serious toll on physiological health and psychological well-being. Cortisol is an essential biomarker of stress because of the close relationship between cortisol concentration in the human body and stress level. In this study, a flexible LSPR biosensor was manufactured to detect cortisol levels in the human body by depositing gold nanoparticle (AuNP) layers on a 3-aminopropyltriethoxysilane (APTES)-functionalized poly (dimethylsiloxane) (PDMS) substrate. Subsequently, an aptamer was immobilized on the surface of the LSPR substrate, enabling highly sensitive and selective cortisol capture owing to its specific cortisol recognition. The biosensor exhibited excellent detection ability in cortisol solutions of various concentrations ranging from 0.1 to 1000 nM with a detection limit of 0.1 nM. The flexible LSPR biosensor also demonstrated good stability under various mechanical deformations. Furthermore, the cortisol levels of the flexible LSPR biosensor were also measured in the human epidermis before and after exercise as well as in the morning and afternoon. Our biosensors, which combine easily manufactured flexible sensors with sensitive cortisol-detecting molecules to measure human stress levels, could be versatile candidates for human-friendly products.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
完美世界应助科研通管家采纳,获得10
刚刚
刚刚
共享精神应助科研通管家采纳,获得10
刚刚
小蘑菇应助科研通管家采纳,获得10
刚刚
在水一方应助科研通管家采纳,获得10
1秒前
ShowMaker应助科研通管家采纳,获得30
1秒前
星希应助科研通管家采纳,获得10
1秒前
小马甲应助科研通管家采纳,获得10
1秒前
ShowMaker应助科研通管家采纳,获得30
1秒前
1秒前
夏夏1992发布了新的文献求助10
3秒前
星辰大海应助无与伦比采纳,获得10
3秒前
4秒前
务实的宛完成签到,获得积分10
4秒前
redking完成签到,获得积分10
4秒前
竹筏过海应助危机的芸采纳,获得30
4秒前
6秒前
大个应助寒冰采纳,获得10
7秒前
水知寒完成签到,获得积分10
8秒前
潇潇暮雨完成签到,获得积分10
8秒前
9秒前
9秒前
9秒前
9秒前
夜雨完成签到,获得积分10
10秒前
谨慎达发布了新的文献求助10
11秒前
领导范儿应助任逍遥采纳,获得10
11秒前
11秒前
JamesPei应助马里奥采纳,获得10
12秒前
12秒前
CYQQ完成签到,获得积分10
13秒前
小不胖鼠发布了新的文献求助20
13秒前
无与伦比发布了新的文献求助10
14秒前
动人的邑发布了新的文献求助10
14秒前
野生菜狗发布了新的文献求助10
17秒前
逗号先生完成签到,获得积分20
17秒前
18秒前
坚强丹雪完成签到,获得积分10
19秒前
20秒前
方远锋完成签到,获得积分10
20秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3151736
求助须知:如何正确求助?哪些是违规求助? 2803153
关于积分的说明 7852024
捐赠科研通 2460525
什么是DOI,文献DOI怎么找? 1309844
科研通“疑难数据库(出版商)”最低求助积分说明 629061
版权声明 601760