纳米复合材料
核化学
纳米颗粒
材料科学
壳聚糖
静电纺丝
透射电子显微镜
伤口愈合
咪唑酯
MTT法
纳米纤维
化学工程
纳米技术
化学
聚合物
有机化学
复合材料
细胞生长
医学
免疫学
工程类
生物化学
作者
Mahdi Barjasteh,Seyed Mohsen Dehnavi,Shahab Ahmadi Seyedkhani,Seyed Yahya Rahnamaee,Mortaza Golizadeh
标识
DOI:10.1016/j.ijpharm.2022.122339
摘要
In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80-110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5-20 nm Ag nanoparticles. MTT assay indicated excellent cell viability values of ∼115 and 109% for the CS/BC nanocomposites reinforced by ZIF-8 and Ag@ZIF-8 nanoparticles, respectively. The Ag-containing wound dressings showed 52-300% of effective antibacterial activities. Animal studies demonstrated excellent healing for the wound treated by CS/BC-25%Ag@ZIF-8 nanocomposite with ∼91% of wound closure after 14 days of treatment. Hematoxylin and eosin (H&E) staining revealed successful healing and tissue regeneration for the wounds treated using the CS/BC-Ag@ZIF-8 nanocomposites. This kind of nanocomposites with synergistic antimicrobial and bioactivity properties can be a promising candidate for regenerative medicine.
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