土曲霉
化学
立体化学
聚酮
双键
乙醚
天然产物
IC50型
吲哚试验
内酯
体外
生物化学
生物合成
有机化学
基因
作者
Yuwei Zhou,Xiaocong Chen,Yuqian Tang,Yena Liu,Zhongxiang Zhao,Hui Cui
标识
DOI:10.1080/14786419.2022.2140338
摘要
Chemical epigenetic manipulation of Aspergillus terreus GZU-31-1 led to the discovery of five butanolide derivatives (1–5), including two new ones (1 and 2), and four known diphenyl ether derivatives (6−9). Compound 1 featured a Z-configuration double bond in the isoprenyl group was a potential anti-inflammatory bioactive group. Compound 2 was a new natural product. Moreover, compound 3 with a deacetylated group at C-4 was rarely reported as a butanolide analogue, which was isolated from the liquid culture treated with polyketide pathway inhibitor sodium citrate dihydrate. All of the isolates (1−9) were tested for their anti-inflammatory effects on the production of nitric oxide in lipopolysaccharide-induced microglial cells (RAW 264.7 cells). Compounds 1, 7, 8 and 9 exhibited more potent anti-inflammatory activity with IC50 values of 16.31, 20.16, 9.53 and 21.64 μM than the positive control (indomethacin, IC50, 24.0 μM).
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