前脑
人脑
生物
大脑发育
神经科学
电池类型
少突胶质细胞
细胞
转录组
进化生物学
中枢神经系统
基因
遗传学
髓鞘
基因表达
作者
Emelie Braun,Miri Danan-Gotthold,Lars E. Borm,Elin Vinsland,Ka Wai Lee,Peter Lönnerberg,Lijuan Hu,Xiaofei Li,Xiaoling He,Žaneta Andrusivová,Joakim Lundeberg,Ernest Arenas,Roger A. Barker,Erik Sundström,Sten Linnarsson
标识
DOI:10.1101/2022.10.24.513487
摘要
The adult human brain likely comprises more than a thousand kinds of neurons, and an unknown number of glial cell types, but how cellular diversity arises during early brain development is not known. Here, in order to reveal the precise sequence of events during early brain development, we used single-cell RNA sequencing and spatial transcriptomics to uncover cell states and trajectories in human brains at 5 – 14 post-conceptional weeks (p.c.w.). We identified twelve major classes and over 600 distinct cell states, which mapped to precise spatial anatomical domains at 5 p.c.w. We uncovered detailed differentiation trajectories of the human forebrain, and a surprisingly large number of region-specific glioblasts maturing into distinct pre-astrocytes and pre-oligodendrocyte precursor cells (pre-OPCs). Our findings reveal the emergence of cell types during the critical first trimester of human brain development.
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