抗菌肽
细胞内
抗菌剂
生物
抗生素
细胞内寄生虫
微生物学
细菌
计算生物学
先天免疫系统
细胞生物学
免疫学
免疫系统
遗传学
作者
Mohammad Moradi,Saeid Besharati,Mehrdad Moosazadeh Moghaddam,Mahdi Fasihi‐Ramandi,Zohreh Mohammadi Azad,Reza Mirnejad
出处
期刊:The Journal of Microbiology, Biotechnology and Food Sciences
[Slovak University of Agriculture in Nitra]
日期:2022-11-28
卷期号:: e6006-e6006
被引量:2
摘要
Multi-drug resistance, which is the consequence of overusing antibiotics, has been shown to become a common problem in the medical environments. Accordingly, finding a substitute for daily used antibiotics is a topic of interest in medical microbiology and biotechnology. Antimicrobial peptides (AMPs) are among the main candidates for controlling this problem. These peptides are regarded as the critical defensive line in many organisms. These AMPs act as an innate immunity against pathogenic microorganisms; such as bacteria or fungi. AMPs could destroy their target via different methods; including membrane pore-formation or by targeting their intracellular targets and disrupting the normal cellular activity. Some AMPs have the property of targeting constructs like DNA, RNA, protein synthesis and folding and inhibiting cell life activities; such as normal metabolism or cell division. At this study, we reviewed more than 130 papers that were concerning the importance of intracellular targeting AMPs, by searching the valuable data sources such as PubMed, Scopus, and Web of Science. These AMPs can be considered as one of the possible options to improve the treatment of infected patients. In this review, it was aimed to discuss the activity of intracellular AMPs and provide an outlook for future studies.
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