Enhanced long-lasting luminescence nanorods for ultrasensitive detection of SARS-CoV-2 N protein

发光 余辉 生物传感器 持续发光 材料科学 纳米棒 检出限 纳米技术 荧光 纳米材料 纳米颗粒 光电子学 化学 热释光 光学 色谱法 物理 伽马射线暴 天文
作者
Yi Wei,Menglin Song,Lihua Li,Yingjin Ma,Xinyue Lao,Yuan Liu,Guogang Li,Jianhua Hao
出处
期刊:Science China. Materials [Springer Nature]
卷期号:68 (1): 253-260
标识
DOI:10.1007/s40843-024-3148-9
摘要

Abstract Persistent luminescence nanomaterials can remain luminescence when the light source is turned off, which exhibits promise in biosensor and bioimaging fields since they have the ability to completely eradicate tissue autofluorescence. Although significant progress has been made in the persistent luminescence biosensing, there is still a dearth of long-afterglow detection platform with low limit of detection (LOD) and high sensitivity. Herein, Zn 2 GeO 4 :Mn, Cr persistently luminescent nanorods (PLNRs) with superior persistent luminescence and long afterglow time were developed. The addition of Cr 3+ manifestly improves persistent luminescence intensity and afterglow duration through creating a deep defect trap. Then the biosensors were constructed by combining the Zn 2 GeO 4 :Mn,Cr PLNRs-antibody and Fe 3 O 4 magnetic nanoparticles (MNPs)-antibody for nucleocapsid protein detection based on electrostatic attraction. The LOD value for nucleocapsid protein realizes as low as 39.82 ag/mL, which is much lower than the previously reported persistent luminescent-based biosensors. Accordingly, the low detection sensitivity is attributed to fluorescence resonance energy transfer. In addition, high specificity is also achieved. Therefore, the as-prepared Zn 2 GeO 4 :Mn,Cr persistently luminescent materials can act as the promising candidate in biosensors applications. This strategy provides effective guidance for the development of biosensing platforms with high sensitivity and specificity.
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