Access to Functionalized Amines and Medium N-Heterocycles via Amine-Enabled Remote C–H Alkynylation

By using weakly coordinating amines, we developed remote C-H alkynylation with precise control of reactivity and regioselectivity, enabling modification of complex drugs, natural products, and materials. The readily transformable alkyne-containing amine products would facilitate expedient delivery of molecular libraries of functionalized amines and medium