替莫唑胺
泛素
胶质母细胞瘤
酶
化学
灵敏度(控制系统)
癌症研究
生物化学
生物
基因
电子工程
工程类
作者
Lin Xu,Baoju Wang,Zhenbo Gang,Zhibin Han,Aowen Wang,Qi Liu,Hongyang Liu,Shilong Wei,Zhiguo Lin,Chuncheng Xie,Hu Li
标识
DOI:10.1016/j.ijbiomac.2025.140583
摘要
UBE2S plays a critical role in TMZ resistance by stabilizing PGAM1 protein levels through its interaction with OTUB2. Targeting UBE2S represents a promising therapeutic strategy to enhance TMZ efficacy and overcome chemotherapy resistance in GBM.
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