Hox, homology, and parsimony: An organismal perspective

Hox基因 生物 进化生物学 最近的共同祖先 同源(生物学) 系统发育学 基因 遗传学 基因组 谱系(遗传) 进化发育生物学 基因表达
作者
Andreas Wanninger
出处
期刊:Seminars in Cell & Developmental Biology [Elsevier BV]
卷期号:152-153: 16-23 被引量:11
标识
DOI:10.1016/j.semcdb.2023.01.007
摘要

Hox genes are important regulators in animal development. They often show a mosaic of conserved (e.g., longitudinal axis patterning) and lineage-specific novel functions (e.g., development of skeletal, sensory, or locomotory systems). Despite extensive research over the past decades, it remains controversial at which node in the animal tree of life the Hox cluster evolved. Its presence already in the last common metazoan ancestor has been proposed, although the genomes of both putative earliest extant metazoan offshoots, the ctenophores and the poriferans, are devoid of Hox sequences. The lack of Hox genes in the supposedly "simple"-built poriferans and their low number in cnidarians and the basally branching bilaterians, the xenacoelomorphs, seems to support the classical notion that the number of Hox genes is correlated with the degree of animal complexity. However, the 4-fold increase of the Hox cluster in xiphosurans, a basally branching chelicerate clade, as well as the situation in some teleost fishes that show a multitude of Hox genes compared to, e.g., human, demonstrates, that there is no per se direct correlation between organismal complexity and Hox number. Traditional approaches have tried to base homology on the morphological level on shared expression profiles of individual genes, but recent data have shown that, in particular with respect to Hox and other regulatory genes, complex gene-gene interactions rather than expression signatures of individual genes alone are responsible for shaping morphological traits during ontogeny. Accordingly, for sound homology assessments and reconstructions of character evolution on organ system level, additional independent datasets (e.g., morphological, developmental) need to be included in any such analyses. If supported by solid data, proposed structural homology should be regarded as valid and not be rejected solely on the grounds of non-parsimonious distribution of the character over a given phylogenetic topology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
568923完成签到,获得积分10
2秒前
Grace159完成签到 ,获得积分10
5秒前
咖啡博士发布了新的文献求助10
7秒前
彦祖i学术完成签到,获得积分10
9秒前
zq完成签到,获得积分20
10秒前
HY完成签到,获得积分10
11秒前
不再挨训完成签到 ,获得积分10
12秒前
学术乞丐完成签到,获得积分20
14秒前
咖啡博士完成签到,获得积分10
15秒前
韭黄发布了新的文献求助10
16秒前
Singularity完成签到,获得积分0
18秒前
JamesPei应助zq采纳,获得10
19秒前
所所应助韭黄采纳,获得10
23秒前
江霭完成签到,获得积分10
26秒前
鲤鱼青槐完成签到,获得积分10
35秒前
量子星尘发布了新的文献求助10
36秒前
39秒前
缥缈的冰旋完成签到,获得积分10
39秒前
45秒前
46秒前
ailemonmint完成签到 ,获得积分10
46秒前
47秒前
玉ER完成签到,获得积分10
48秒前
49秒前
四十四次日落完成签到 ,获得积分10
49秒前
科研通AI2S应助羊二呆采纳,获得10
49秒前
英吉利25发布了新的文献求助10
51秒前
52秒前
水晶茶杯发布了新的文献求助10
53秒前
欢欢完成签到,获得积分10
54秒前
茯苓完成签到 ,获得积分10
56秒前
小鱼发布了新的文献求助10
57秒前
香香丿完成签到 ,获得积分10
57秒前
58秒前
万能图书馆应助zz123采纳,获得10
58秒前
杜康完成签到,获得积分10
58秒前
Cheung2121发布了新的文献求助10
58秒前
医学小王完成签到 ,获得积分10
59秒前
1分钟前
刘涵完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038112
求助须知:如何正确求助?哪些是违规求助? 3575788
关于积分的说明 11373801
捐赠科研通 3305604
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022