亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Development and Validation of a Nomogram to Predict Significant Liver Inflammation in Patients with Chronic Hepatitis B

列线图 医学 接收机工作特性 凝血酶原时间 肝活检 内科学 逻辑回归 胃肠病学 丙氨酸转氨酶 活检
作者
Suling Jiang,Jian Wang,Zhiyi Zhang,Jie Zhan,Ruifei Xue,Yuanwang Qiu,Liguo Zhu,S. Zhang,Yifan Pan,Xiaomin Yan,Yuxin Chen,Jie Liu,Xingxiang Liu,Chuanwu Zhu,Rui Huang,Chao Wu
出处
期刊:Infection and Drug Resistance [Dove Medical Press]
卷期号:Volume 16: 5065-5075
标识
DOI:10.2147/idr.s417007
摘要

Noninvasive diagnosis of liver inflammation is important for patients with chronic hepatitis B (CHB). This study aimed to develop a nomogram to predict significant liver inflammation for CHB patients.CHB patients who underwent liver biopsy were retrospectively collected and randomly divided into a development set and a validation set. The least absolute shrinkage and selection operator regression and logistic regression analysis were used to select independent predictors of significant liver inflammation, and a nomogram was developed. The performance of nomogram was assessed by receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA).A total of 1019 CHB patients with a median age of 39.0 years were included. Alanine aminotransaminase (ALT, P = 0.018), gamma-glutamyl transpeptidase (P = 0.013), prothrombin time (P < 0.001), and HBV DNA level (P = 0.030) were identified as independent predictors of significant liver inflammation in the development set. A model namely AGPD-nomogram was developed based on the above parameters. The area under the ROC curve in predicting significant inflammation was 0.765 (95% CI: 0.727-0.803) and 0.766 (95% CI: 0.711-0.821) in the development and validation sets, which were significantly higher than other indexes. The AGPD-nomogram had a high predictive value in patients with normal ALT. Moreover, the nomogram was proven to be clinically useful by DCA.A visualized AGPD-nomogram which incorporated routine clinical parameters was proposed to facilitate the prediction of significant liver inflammation in CHB patients. This nomogram had high accuracy in the identification of significant liver inflammation and would be a useful tool for the better management of CHB patients, especially for those with normal ALT.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
几两完成签到 ,获得积分10
1秒前
6秒前
10秒前
ni完成签到,获得积分10
15秒前
思源应助Nacy采纳,获得10
20秒前
20秒前
31秒前
34秒前
34秒前
852应助研友_Zzrx6Z采纳,获得80
35秒前
35秒前
36秒前
ForeverAE发布了新的文献求助10
39秒前
40秒前
Nacy发布了新的文献求助10
42秒前
ZHErain发布了新的文献求助10
46秒前
47秒前
124332发布了新的文献求助10
53秒前
1分钟前
CipherSage应助科研通管家采纳,获得10
1分钟前
NexusExplorer应助124332采纳,获得10
1分钟前
1分钟前
1分钟前
124332发布了新的文献求助80
1分钟前
研友_Zzrx6Z发布了新的文献求助80
1分钟前
1分钟前
乐乐发布了新的文献求助10
1分钟前
3469907229完成签到 ,获得积分10
1分钟前
1分钟前
搜集达人应助Nacy采纳,获得10
1分钟前
Lucas应助丝瓜采纳,获得10
1分钟前
CATH完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
Nacy发布了新的文献求助10
1分钟前
XT666发布了新的文献求助20
2分钟前
2分钟前
XT666完成签到,获得积分10
2分钟前
清脆的夜云完成签到,获得积分10
2分钟前
不易完成签到,获得积分20
2分钟前
高分求助中
Rock-Forming Minerals, Volume 3C, Sheet Silicates: Clay Minerals 2000
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 930
The Vladimirov Diaries [by Peter Vladimirov] 600
Development of general formulas for bolted flanges, by E.O. Waters [and others] 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3265467
求助须知:如何正确求助?哪些是违规求助? 2905482
关于积分的说明 8333920
捐赠科研通 2575775
什么是DOI,文献DOI怎么找? 1400130
科研通“疑难数据库(出版商)”最低求助积分说明 654702
邀请新用户注册赠送积分活动 633525