内质网
未折叠蛋白反应
精子发生
氧化应激
功能(生物学)
生物
炎症
内分泌学
内科学
细胞生物学
医学
作者
Mohsen Rahmani,Marziyeh Tavalaee,Joël R. Drevet,Mohammad Hossein Nasr-Esfahani
出处
期刊:PubMed
日期:2023-07-25
卷期号:25 (7): 437-446
被引量:1
标识
DOI:10.22074/cellj.2023.1983074.1205
摘要
Testicular dysfunction, whether linked to varicocele, obesity, diabetes, aging, inflammation, or lifestyle or environmental issues, is frequently accompanied by an accumulation of unfolded or misfolded proteins, indicating impaired endoplasmic reticulum (ER) function. In this review, we examined the Google Scholar, Scopus and PubMed databases (from 2011 to 2022) to support the association of ER stress with defective spermatogenesis in animal models and humans. ER stress, whether in its pro-survival or pro-apoptotic aspect, appears to be closely linked to each studied situation. Several studies have demonstrated a significant increase in oxidative stress (OS) levels in infertile men compared to fertile individuals, which is associated with poor spermatogenesis quality. OS is likely the result of the interplay between ER stress and spermatogenesis defects. These findings suggest that therapeutic strategies aimed at mitigating both ER stress and OS could be of interest in restoring male reproductive function.
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