硼酸
化学
共价键
催化作用
组合化学
分子识别
化学改性
氨基酸
多元醇
翻译后修饰
糖肽
有机化学
生物化学
分子
酶
聚氨酯
抗生素
作者
Reyner D. Vargas,Yuxuan Ding,Hallie O. Trial,Ruoyu Qian,Zachary T. Ball
摘要
Proximity-induced methodologies for peptide and protein modification have been developed using recognition elements like inhibitors, antibodies, or affinity tags on amino acids. However, the recognition of saccharides for chemical modification remains widely unexplored. Studies exploring boronic acids and their derivatives have shown their alluring capabilities as selective molecular recognition elements for saccharides, and in this study we describe the application of these ideas to the discovery of a catalytic proximity-induced methodology for covalent modification of glycopeptides using boronic acids as a saccharide recognition element.
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