亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

KRAS G12C mutation in metastatic colorectal cancer: a new target

结直肠癌 克拉斯 医学 癌症 肿瘤科 内科学
作者
Rebecca Ibrahim,Khalil Saleh,Claude Chahine,Rita Khoury,Nadine Khalife,A. Lecesne
出处
期刊:Future Oncology [Future Medicine]
卷期号:19 (24): 1641-1643
标识
DOI:10.2217/fon-2023-0223
摘要

Future OncologyVol. 19, No. 24 EditorialKRASG12C mutation in metastatic colorectal cancer: a new targetRebecca Ibrahim, Khalil Saleh, Claude Chahine, Rita Khoury, Nadine Khalife & Axel LecesneRebecca IbrahimInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France, Khalil Saleh *Author for correspondence: Tel.: +33 142 114 211; E-mail Address: khalil_saleh@live.comhttps://orcid.org/0000-0002-2985-2202International Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France, Claude ChahineInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France, Rita KhouryInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France, Nadine KhalifeDepartment of Head & Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, 94800, France & Axel LecesneInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FrancePublished Online:21 Aug 2023https://doi.org/10.2217/fon-2023-0223AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: adagrasibcolorectal cancerKRASG12C mutationRASsotorasibReferences1. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 14(2), 89–103 (2019).Medline, CAS, Google Scholar2. Tariq K, Ghias K. Colorectal cancer carcinogenesis: a review of mechanisms. Cancer Biol. Med. 13(1), 120–135 (2016).Crossref, Medline, CAS, Google Scholar3. Won DD, Lee JI, Lee IK, Oh S-T, Jung ES, Lee SH. The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients. BMC Cancer 17(1), 403 (2017).Crossref, Medline, Google Scholar4. Jancík S, Drábek J, Radzioch D, Hajdúch M. Clinical relevance of KRAS in human cancers. J. Biomed. Biotechnol. 2010, 150960 (2010).Crossref, Medline, Google Scholar5. Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol. Res. Pract. 205(12), 858–862 (2009).Crossref, Medline, CAS, Google Scholar6. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503(7477), 548–551 (2013).Crossref, Medline, CAS, Google Scholar7. Jones RP, Sutton PA, Evans JP et al. Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer. Br. J. Cancer 116(7), 923–929 (2017).Crossref, Medline, CAS, Google Scholar8. Reck M, Carbone DP, Garassino M, Barlesi F. Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches. Ann. Oncol. 32(9), 1101–1110 (2021).Crossref, Medline, CAS, Google Scholar9. Skoulidis F, Li BT, Dy GK et al. Sotorasib for lung cancers with KRAS p.G12C mutation. N. Engl. J. Med. 384(25), 2371–2381 (2021).Crossref, Medline, CAS, Google Scholar10. Fakih MG, Kopetz S, Kuboki Y et al. Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial. Lancet Oncol. 23(1), 115–124 (2022).Crossref, Medline, CAS, Google Scholar11. Weiss J, Yaeger RD, Johnson ML et al. LBA6 KRYSTAL-1: adagrasib (MRTX849) as monotherapy or combined with cetuximab (Cetux) in patients (pts) with colorectal cancer (CRC) harboring a KRASG12C mutation. Ann. Oncol. 32(Suppl. 5), S1294 (2021).Crossref, Medline, Google Scholar12. Goebel L, Müller MP, Goody RS, Rauh D. KRasG12C inhibitors in clinical trials: a short historical perspective. RSC Med. Chem. 11(7), 760–770 (2020).Crossref, Medline, CAS, Google Scholar13. Singh A, Greninger P, Rhodes D et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell 15(6), 489–500 (2009).Crossref, Medline, CAS, Google Scholar14. Prenen H, Fakih M, Falchook G et al. SO-39 evaluation of acquired resistance to sotorasib in KRAS p.G12C-mutated colorectal cancer: exploratory plasma biomarker analysis of CodeBreaK 100. Ann. Oncol. 33(Suppl. 4), S373 (2022).Crossref, Google Scholar15. Amodio V, Yaeger R, Arcella P et al. EGFR blockade reverts resistance to KRASG12C inhibition in colorectal cancer. Cancer Discov. 10(8), 1129–1139 (2020).Crossref, Medline, CAS, Google Scholar16. Ryan MB, Coker O, Sorokin A et al. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep. 39(12), 110993 (2022).Crossref, Medline, CAS, Google Scholar17. Kuboki Y, Yaeger R, Fakih M et al. 45MO sotorasib in combination with panitumumab in refractory KRAS G12C-mutated colorectal cancer: safety and efficacy for phase Ib full expansion cohort. Ann. Oncol. 33(Suppl. 9), S1445–S1446 (2022).Crossref, Google Scholar18. Yaeger R, Weiss J, Pelster MS et al. Adagrasib with or without cetuximab in colorectal cancer with mutated KRAS G12C. New Engl. J. Med. 388(1), 44–54 (2023).Crossref, Medline, CAS, Google Scholar19. Yaeger R, Mezzadra R, Sinopoli J et al. Molecular characterization of acquired resistance to KRASG12C-EGFR inhibition in colorectal cancer. Cancer Discov. 13(1), 41–55 (2023).Crossref, Medline, CAS, Google Scholar20. Canon J, Rex K, Saiki AY et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature 575(7781), 217–223 (2019).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 19, No. 24 STAY CONNECTED Metrics Downloaded 76 times History Received 19 March 2023 Accepted 18 July 2023 Published online 21 August 2023 Published in print August 2023 Information© 2023 Future Medicine LtdKeywordsadagrasibcolorectal cancerKRASG12C mutationRASsotorasibFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Langsam发布了新的文献求助30
2秒前
耍酷代柔完成签到,获得积分10
8秒前
11秒前
18秒前
45秒前
50秒前
智商还在加载完成签到,获得积分10
57秒前
小涂大大发布了新的文献求助20
58秒前
58秒前
欧皇完成签到,获得积分10
1分钟前
战神林北完成签到,获得积分10
1分钟前
科研通AI2S应助烽烽烽采纳,获得10
1分钟前
科研通AI2S应助小涂大大采纳,获得10
1分钟前
凭风听纸鸢完成签到,获得积分10
1分钟前
make217完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
1分钟前
Ava应助坤坤爱文献采纳,获得10
1分钟前
清爽幼枫发布了新的文献求助10
1分钟前
1分钟前
坤坤爱文献完成签到,获得积分10
1分钟前
1分钟前
winkyyang完成签到 ,获得积分10
1分钟前
王提发布了新的文献求助10
1分钟前
郁李完成签到,获得积分10
2分钟前
2分钟前
2分钟前
卧镁铀钳完成签到 ,获得积分10
2分钟前
2分钟前
EgbertW关注了科研通微信公众号
2分钟前
rainbow完成签到 ,获得积分10
2分钟前
研学完成签到,获得积分10
2分钟前
康康完成签到 ,获得积分10
2分钟前
wu关闭了wu文献求助
3分钟前
CMUSK完成签到,获得积分10
3分钟前
man完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
【本贴是提醒信息,请勿应助】请在求助之前详细阅读求助说明!!!! 20000
Evolution 4000
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
La Chine révolutionnaire d'aujourd'hui / Van Min, Kang Hsin 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3038009
求助须知:如何正确求助?哪些是违规求助? 2696762
关于积分的说明 7358507
捐赠科研通 2338690
什么是DOI,文献DOI怎么找? 1238051
科研通“疑难数据库(出版商)”最低求助积分说明 602692
版权声明 595101