Multi-omic approaches provide insights into the molecular mechanisms of Sojae semen germinatum water extract against overactive bladder

膀胱过度活动 染料木素 污渍 药理学 生物 医学 化学 内科学 生物化学 病理 基因 替代医学
作者
Mingchang Cheng,Yining Qiang,Yu-Shan Wu,Xinyi Tong,Tie Yan,Zhihui Sun,Shenghan Guan,Liping Xu,Pingxiang Xu,Xiaorong Li,Ming Xue,Xuelin Zhou
出处
期刊:Food Research International [Elsevier]
卷期号:175: 113746-113746 被引量:2
标识
DOI:10.1016/j.foodres.2023.113746
摘要

Sojae semen germinatum (SSG) is derived from mature soybean seeds that have been germinated and dried, typically with sprouts measuring approximately 0.5 cm in length. SSG is traditionally known for its properties in clearing heat and moisture. Nevertheless, limited information was reported on the effects and mechanisms of SSG in alleviating urinary symptoms. This study employed urodynamic parameters to investigate the therapeutic effect of SSG water extract on overactive bladder (OAB) in the rat model with benign prostatic hyperplasia. Through a combination of transcriptomic and metabolomic analyses, the pathways and key proteins of the SSG treatment for OAB were identified and validated by ELISA and Western blotting. Furthermore, network pharmacology elucidated the roles of SSG's isoflavones acting on the target which was identified by above-mentioned multi-omics analysis. Our results indicate that SSG water extract significantly mitigated OAB by down-regulating the PGE2/EP1/PLCβ2/p-MLC signaling pathway. It was speculated that the active ingredient in the SSG on EP1 was genistein. This study provided valuable insights into the molecular mechanisms of SSG water extract, emphasizing the multi-target characteristics and critical pathways in improving OAB. Furthermore, this study contributes to the potential utilization of SSG as a functional food.
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