生物
感觉系统
神经科学
生物神经网络
神经元回路
作者
Benjamin T. Throesch,Muhammad Khadeesh bin Imtiaz,Rodrigo Muñoz-Castañeda,Masahiro Sakurai,Andrea L. Hartzell,Kiely N. James,Alberto R. Rodriguez,Greg Martin,Giordano Lippi,Sergey Kupriyanov,Zhuhao Wu,Pavel Osten,Juan Carlos Izpisúa Belmonte,Jun Wu,Kristin K. Baldwin
出处
期刊:Cell
[Elsevier]
日期:2024-04-01
卷期号:187 (9): 2143-2157.e15
被引量:5
标识
DOI:10.1016/j.cell.2024.03.042
摘要
A central question for regenerative neuroscience is whether synthetic neural circuits, such as those built from two species, can function in an intact brain. Here, we apply blastocyst complementation to selectively build and test interspecies neural circuits. Despite approximately 10-20 million years of evolution, and prominent species differences in brain size, rat pluripotent stem cells injected into mouse blastocysts develop and persist throughout the mouse brain. Unexpectedly, the mouse niche reprograms the birth dates of rat neurons in the cortex and hippocampus, supporting rat-mouse synaptic activity. When mouse olfactory neurons are genetically silenced or killed, rat neurons restore information flow to odor processing circuits. Moreover, they rescue the primal behavior of food seeking, although less well than mouse neurons. By revealing that a mouse can sense the world using neurons from another species, we establish neural blastocyst complementation as a powerful tool to identify conserved mechanisms of brain development, plasticity, and repair.
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