中性粒细胞胞外陷阱
NADPH氧化酶
炎症
染色质
细胞生物学
组蛋白
细胞外
生物
胞浆
功能(生物学)
免疫学
化学
活性氧
生物化学
基因
酶
作者
Yijie Wang,Chunjing Du,Yue Zhang,Liuluan Zhu
出处
期刊:Biomolecules
[MDPI AG]
日期:2024-03-29
卷期号:14 (4): 416-416
被引量:5
摘要
Neutrophil extracellular traps (NETs) are intricate fibrous structures released by neutrophils in response to specific stimuli. These structures are composed of depolymerized chromatin adorned with histones, granule proteins, and cytosolic proteins. NETs are formed via two distinct pathways known as suicidal NETosis, which involves NADPH oxidase (NOX), and vital NETosis, which is independent of NOX. Certain proteins found within NETs exhibit strong cytotoxic effects against both pathogens and nearby host cells. While NETs play a defensive role against pathogens, they can also contribute to tissue damage and worsen inflammation. Despite extensive research on the pathophysiological role of NETs, less attention has been paid to their components, which form a unique structure containing various proteins that have significant implications in a wide range of diseases. This review aims to elucidate the components of NETs and provide an overview of their impact on host defense against invasive pathogens, autoimmune diseases, and cancer.
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