Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease

神经退行性变 淋巴系统 认知功能衰退 痴呆 萎缩 疾病 匹兹堡化合物B 淀粉样蛋白(真菌学) 医学 正电子发射断层摄影术 阿尔茨海默病 神经影像学 神经科学 病理 内科学 心理学 脑脊液
作者
Shu‐Yi Huang,Ya‐Ru Zhang,Yu Guo,Jing Du,Peng Ren,Bang‐Sheng Wu,Jianfeng Feng,Wei Cheng,Jin‐Tai Yu
出处
期刊:Alzheimers & Dementia [Wiley]
卷期号:20 (5): 3251-3269 被引量:51
标识
DOI:10.1002/alz.13789
摘要

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS Whole‐brain glymphatic activity was measured by diffusion tensor image analysis along the perivascular space (DTI‐ALPS) in participants with AD dementia ( n = 47), mild cognitive impairment (MCI; n = 137), and normal controls ( n = 235) from the Alzheimer's Disease Neuroimaging Initiative. RESULTS ALPS index was significantly lower in AD dementia than in MCI or controls. Lower ALPS index was significantly associated with faster changes in amyloid positron emission tomography (PET) burden and AD signature region of interest volume, higher risk of amyloid‐positive transition and clinical progression, and faster rates of amyloid‐ and neurodegeneration‐related cognitive decline. Furthermore, the associations of the ALPS index with cognitive decline were fully mediated by amyloid PET and brain atrophy. DISCUSSION Glymphatic failure may precede amyloid pathology, and predicts amyloid deposition, neurodegeneration, and clinical progression in AD. Highlights The analysis along the perivascular space (ALPS) index is reduced in patients with Alzheimer's disease (AD) dementia, prodromal AD, and preclinical AD. Lower ALPS index predicted accelerated amyloid beta (Aβ) positron emission tomography (PET) burden and Aβ‐positive transition. The decrease in the ALPS index occurs before cerebrospinal fluid Aβ42 reaches the positive threshold. ALPS index predicted brain atrophy, clinical progression, and cognitive decline. Aβ PET and brain atrophy mediated the link of ALPS index with cognitive decline.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
XHH完成签到 ,获得积分0
刚刚
进击的然完成签到,获得积分10
刚刚
Zachary完成签到,获得积分10
1秒前
1秒前
xjb完成签到 ,获得积分10
1秒前
君君应助翁雁丝采纳,获得10
2秒前
怡然的白开水完成签到,获得积分10
2秒前
2秒前
FOODHUA完成签到,获得积分10
2秒前
飞翔的梦发布了新的文献求助10
3秒前
典雅碧空应助落后秋烟采纳,获得10
3秒前
Himanny完成签到,获得积分10
3秒前
月半完成签到,获得积分10
3秒前
1028181661发布了新的文献求助10
3秒前
3秒前
早早完成签到,获得积分10
3秒前
西方印迹大王完成签到 ,获得积分10
4秒前
小刺猬发布了新的文献求助10
4秒前
蓉儿完成签到 ,获得积分10
4秒前
清爽乐菱应助dearwang采纳,获得30
5秒前
酷酷的冰真应助dearwang采纳,获得30
5秒前
冷酷丹翠发布了新的文献求助10
5秒前
dhn123发布了新的文献求助20
5秒前
6秒前
林夕完成签到,获得积分10
6秒前
6秒前
tuzi123完成签到,获得积分10
6秒前
小蚂蚁发布了新的文献求助10
7秒前
Vera完成签到,获得积分10
8秒前
8秒前
8秒前
生命奋斗发布了新的文献求助20
8秒前
神勇初瑶完成签到,获得积分10
9秒前
9秒前
6789发布了新的文献求助10
9秒前
9秒前
淡然的奎完成签到,获得积分10
9秒前
冬冬完成签到,获得积分10
10秒前
Owen应助1028181661采纳,获得10
10秒前
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968719
求助须知:如何正确求助?哪些是违规求助? 3513608
关于积分的说明 11168681
捐赠科研通 3248960
什么是DOI,文献DOI怎么找? 1794573
邀请新用户注册赠送积分活动 875194
科研通“疑难数据库(出版商)”最低求助积分说明 804716