Blinatumoab公司
医学
内科学
化疗
微小残留病
急性淋巴细胞白血病
入射(几何)
诱导化疗
胃肠病学
肿瘤科
淋巴细胞白血病
白血病
物理
光学
作者
Jing Lu,Huifen Zhou,Xin Zhou,Yonggong Yang,Laigen Tong,Miao Miao,Xiaofei Yang,Suning Chen
摘要
Blinatumomab early-line treatment in B-cell precursor acute lymphoblastic leukemia (B-ALL) might improve clinical outcomes.We conducted a retrospective real-world cohort analysis in 20 newly diagnosed B-ALL patients who received reduced-dose chemotherapy (idarubicin, vindesine, and dexamethasone) for 1-3 weeks, followed by blinatumomab for 1-4 weeks as an induction therapy.At the end of the induction therapy, a complete remission rate of 100% was achieved; 17 (85%) patients were minimal residual disease (MRD) negative (<1 × 10-4 ). Adverse events (AEs) were reported in 12 (60%) patients-43.8% were grade 1-2 and 56.2% were grade 3-4. No incidence of neurotoxicity or grade ≥3 cytokine release syndrome was reported.Blinatumomab demonstrated a significant improvement in clinical outcomes in patients with newly diagnosed B-ALL irrespective of their poor-risk factor status and the pretreatment blast burden.
科研通智能强力驱动
Strongly Powered by AbleSci AI