Comparison of New Bronchopulmonary Dysplasia Definitions on Long-Term Outcomes in Preterm Infants

Abstract

Objectives

To compare the discriminative performances of the 2018-National Institutes of Health (NIH) and the 2019-Jensen bronchopulmonary dysplasia (BPD) definitions to the 2001- (NIH) definition on neurodevelopmental and respiratory adverse outcome at two- and five years corrected age (CA).

Study design

In this single center retrospective cohort study, outcomes of infants born at a gestational age < 30 weeks were collected. The three BPD definitions were compared by adding the different definitions to the National Institute Child Health and Human Development outcome prediction model for neurodevelopmental impairment or death. Discriminative performance was compared for both outcomes at two- and five years CA by calculating the areas under the receiver operating characteristic curve and Z-statistics.

Results

The presence of BPD and its severity was determined in 584 infants. There were considerable shifts in BPD grading between the different definitions. At both time points, all BPD definition models had comparable discriminating power for neurodevelopmental impairment and respiratory morbidity with one exception. Compared with the 2001-NIH definition, the 2018-NIH definition had less predictive power for the neurological outcome at two years CA.

Conclusion

Comparison of three BPD definitions shows similar discriminative performance on long term neurodevelopmental and respiratory outcomes at two- and five years CA.