Prevention of clinically significant post-EMR bleeding: To clip or not to clip?

Endoscopic mucosal resection (EMR) is the existing standard of care for the management of large nonpedunculated colon polyps (LNPCPs), having a high safety and cost profile compared with other resection techniques such as endoscopic submucosal dissection and surgery.1 Adverse events (AEs) related to EMR include post-EMR bleeding, perforation, and postpolypectomy syndrome. Clinically significant post-EMR bleeding (CSPEB) occurs in 5% to 7.2% of cases and is more common in the right side of the colon.