Artificial intelligence–assisted oculo‐gait measurements for cognitive impairment in cerebral small vessel disease

队列 物理医学与康复 步态 认知 扫视 跨步 逻辑回归 心理学 医学 物理疗法 内科学 神经科学 眼球运动
作者
Huimin Chen,Hao Du,Fang Yi,Tingting Wang,Shuo Yang,Yuesong Pan,Hongyi Yan,Dandan Liu,Mengyuan Zhou,Yiyi Chen,Mengxi Zhao,Jingtao Pi,Yingying Yang,Xiangmin Fan,Xueli Cai,Ziyu Qiu,Jipeng Zhang,Yawei Liu,Wenping Gu,Yilong Wang
出处
期刊:Alzheimers & Dementia [Wiley]
被引量:1
标识
DOI:10.1002/alz.14288
摘要

Abstract INTRODUCTION Oculomotor and gait dysfunctions are closely associated with cognition. However, oculo‐gait patterns and their correlation with cognition in cerebral small vessel disease (CSVD) remain unclear. METHODS Patients with CSVD from a hospital‐based cohort ( n = 194) and individuals with presumed early CSVD from a community‐based cohort ( n = 319) were included. Oculo‐gait patterns were measured using the artificial intelligence (AI) –assisted ‘EyeKnow’ eye‐tracking and ‘ReadyGo’ motor evaluation systems. Multivariable linear and logistic regression models were employed to investigate the association between the oculo‐gait parameters and cognition. RESULTS Anti‐saccade accuracy, stride velocity, and swing velocity were significantly associated with cognition in both patients and community dwellers with CSVD, and could identify cognitive impairment in CSVD with moderate accuracy (area under the curve [AUC]: hospital cohort, 0.787; community cohort, 0.810) after adjusting for age and education. DISCUSSION The evaluation of oculo‐gait features (anti‐saccade accuracy, stride velocity, and swing velocity) may help screen cognitive impairment in CSVD. Highlights Oculo‐gait features (lower anti‐saccade accuracy, stride velocity, and swing velocity) were associated with cognitive impairment in cerebral small vessel disease (CSVD). Logistic model integrating the oculo‐gait features, age, and education level moderately distinguished cognitive status in CSVD. Artificial intelligence–assisted oculomotor and gait measurements provide quick and accurate evaluation in hospital and community settings.
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