Chiral metal-organic frameworks materials for racemate resolution

Chirality, which is involved in the origin and evolution of life, is a very interesting natural property. Pure enantiomers play a crucial role in the safety and health of organisms. Racemate resolution is one of the effective methods to obtain pure enantiomers. Chiral metal-organic frameworks materials (CMOF) have shown great potential in racemic resolution. In this review, the synthetic strategies of chiral metal-organic frameworks are systematically analyzed and discussed based on the resolution mechanism of the racemate in CMOF. In addition, the practical applications of chiral metal-organic frameworks in racemic resolution are comprehensively summarized and classified according to common separation techniques. Last but not least, we address some other issues, including challenges and future prospects in this field. It is hoped that it will be helpful for the development of chiral metal-organic frameworks for racemate resolution.