自噬
免疫疗法
免疫原性细胞死亡
癌症研究
化学
材料科学
免疫系统
细胞凋亡
生物
生物化学
免疫学
作者
Xuehua Long,Huiqi Wang,Jianqin Yan,Yifei Li,Xiaofeng Dong,Sijia Tian,Yong Sun,Kui Luo,Bin He,Yan Liang
出处
期刊:Small
[Wiley]
日期:2023-03-18
卷期号:19 (24)
被引量:12
标识
DOI:10.1002/smll.202207898
摘要
Abstract Chemotherapeutics can induce immunogenic cell death (ICD) by triggering autophagy and mediate antitumor immunotherapy. However, using chemotherapeutics alone can only cause mild cell‐protective autophagy and be incapable of inducing sufficient ICD efficacy. The participation of autophagy inducer is competent to enhance autophagy, so the level of ICD is promoted and the effect of antitumor immunotherapy is highly increased. Herein, tailor‐made autophagy cascade amplification polymeric nanoparticles STF@AHPPE are constructed to enhance tumor immunotherapy. Arginine (Arg), polyethyleneglycol–polycaprolactone, and epirubicin (EPI) are grafted onto hyaluronic acid (HA) via disulfide bond to form the AHPPE nanoparticles and autophagy inducer STF‐62247 (STF) is loaded. When STF@AHPPE nanoparticles target to tumor tissues and efficiently enter into tumor cells with the help of HA and Arg, the high glutathione concentration leads to the cleavage of disulfide bond and the release of EPI and STF. Finally, STF@AHPPE induces violent cytotoxic autophagy and strong ICD efficacy. As compared to AHPPE nanoparticles, STF@AHPPE nanoparticles kill the most tumor cells and show the more obvious ICD efficacy and immune activation ability. This work provides a novel strategy for combining tumor chemo‐immunotherapy with autophagy induction.
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