生物
粒体自噬
线粒体
细胞生物学
线粒体融合
线粒体生物发生
氧化应激
遗传学
线粒体DNA
细胞凋亡
自噬
内分泌学
基因
作者
José Luis Costa,Patrícia C. Braga,Irene Rebelo,Pedro F. Oliveira,Marco G. Alves
出处
期刊:Biology
[MDPI AG]
日期:2023-06-06
卷期号:12 (6): 827-827
被引量:30
标识
DOI:10.3390/biology12060827
摘要
Mitochondria are pivotal to cellular homeostasis, performing vital functions such as bioenergetics, biosynthesis, and cell signalling. Proper maintenance of these processes is crucial to prevent disease development and ensure optimal cell function. Mitochondrial dynamics, including fission, fusion, biogenesis, mitophagy, and apoptosis, maintain mitochondrial quality control, which is essential for overall cell health. In male reproduction, mitochondria play a pivotal role in germ cell development and any defects in mitochondrial quality can have serious consequences on male fertility. Reactive oxygen species (ROS) also play a crucial role in sperm capacitation, but excessive ROS levels can trigger oxidative damage. Any imbalance between ROS and sperm quality control, caused by non-communicable diseases or environmental factors, can lead to an increase in oxidative stress, cell damage, and apoptosis, which in turn affect sperm concentration, quality, and motility. Therefore, assessing mitochondrial functionality and quality control is essential to gain valuable insights into male infertility. In sum, proper mitochondrial functionality is essential for overall health, and particularly important for male fertility. The assessment of mitochondrial functionality and quality control can provide crucial information for the study and management of male infertility and may lead to the development of new strategies for its management.
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