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Acetalized starch-based nanoparticles stabilized acid-sensitive Pickering emulsion as a potential antitumor drug carrier

皮克林乳液 淀粉 纳米颗粒 生物相容性 化学工程 乳状液 化学 药物输送 控制释放 姜黄素 材料科学 核化学 有机化学 纳米技术 生物化学 工程类
作者
Qimeng Zhang,Qifan Zhao,Bingbing Zhu,Rong Chen,Yating Zhou,Xiaopeng Pei,Hua Zhou,Huiyong An,Ying Tan,Chengshui Chen
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:244: 125393-125393 被引量:7
标识
DOI:10.1016/j.ijbiomac.2023.125393
摘要

Pickering emulsions are attracting increased attention owing to their therapeutic applications. However, the slow-release property of Pickering emulsions and the in vivo solid particle accumulation caused by the solid particle stabilizer film limit their applications in therapeutic delivery. In this study, drug-loaded, acid-sensitive Pickering emulsions were prepared using acetal-modified starch-based nanoparticles as stabilizers. The acetalized starch-based nanoparticles (Ace-SNPs) not only act as a solid-particle emulsifier to stabilize Pickering emulsions but also exhibit acid sensitivity and degradability, conducive to the destabilization of Pickering emulsions to release the drug and reduce the effect of particle accumulation in an acidic therapeutic environment. In vitro drug release profiles show that 50 % of curcumin was released in 12 h in an acidic medium (pH 5.4), whereas only 14 % of curcumin was released in 12 h at higher pH (7.4), indicating that the Ace-SNP stabilized Pickering emulsion possess good acid-responsive release characteristics in acidic environments. Moreover, acetalized starch-based nanoparticles and their degradation products showed good biocompatibility, and the resulting curcumin-loaded Pickering emulsions exhibited significant anticancer activity. These features suggest that the acetalized starch-based nanoparticle-stabilized Pickering emulsion has the potential for application as an antitumor drug carrier to enhance therapeutic effects.
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