涂层
微球
材料科学
植入
药品
生物医学工程
药物输送
纳米技术
化学工程
医学
外科
药理学
工程类
作者
Kanike Rajesh,Chandra Khatua,Pushpender Singh,Partha Roy,Anup Kumar Keshri,Debrupa Lahiri
标识
DOI:10.1016/j.jddst.2024.105840
摘要
Implant failure due to infection and weak osseointegration with bone is a serious clinical issue in orthopedic surgery. In this regard, developing an implant surface with long lasting antimicrobial properties, while retaining its bioactivity and mechanical performance, is challenging. Plasma sprayed multilayer porous hydroxyapatite (HA) coatings on Ti6Al4V surface, impregnated with antibiotic, is considered to be a feasible solution. However, sustained drug release for significant duration requires loading of more drug in the coating, as well as, its controlled drug. A multilayer HA coating, comprising of different layers with varying gradient of porosity, can accommodate more drug, while maintaining coating stability simultaneously. The present study introduces an innovative drug loading strategy, where the drug is encapsulated within chitosan microsphere and then dispersed in gelatin polymer (GDC). This structure offers high amount of drug loading in coating and a two-stage barrier for drug diffusion. Additionally, the cross-linking effect in chitosan microsphere and gelatin polymer slow down polymer degradation, resulting in controlled release and making release sustainable for longer duration. The HA coating with gradient porosity is filled with GDC through a vacuum impregnation system. The GDC impregnated sample revealed excellent drug loading (33.20 μg/mm2) and impressive drug release up to 810 h, compared to simple drug-chitosan polymer impregnated HA (drug loading: 27 μg/mm2 and drug release up to 600 h). After filling pores with GDC, fracture toughness is enhanced by 48 % compared to regular HA coating, due to the restriction of crack propagation. Improved tribological properties and enhanced antibacterial efficacy and cytocompatibility are obtained compared to regular HA coated surfaces.
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