光热治疗
乳腺癌
医学
保乳手术
乳腺肿瘤
乳房切除术
癌症
外科
放射科
内科学
材料科学
纳米技术
作者
Wenbo Yu,Ruoxuan Liu,Yangcenzi Xie,Ming Li
标识
DOI:10.1002/adma.202405253
摘要
Abstract Breast‐conserving surgery is the favorable option for breast cancer patients owing to its advantages of less aggressiveness and better cosmetic outcomes over mastectomy. However, it often suffers from postsurgical lethal recurrence due to the incomplete removal of microscopic tumors. Here, a surface‐enhanced Raman scattering (SERS) surgical strategy is reported for precise delineation of tumor margins and intraoperative real‐time elimination of microscopic tumor foci, which is capable of complete surgical removal of breast tumors and significantly improve the outcomes of breast‐conserving surgery without local tumor recurrence. The technique is chiefly based on the human epidermal growth factor receptor 2 (HER2)‐targeting SERS probes with integrated multifunctionalities of ultrahigh sensitive detection, significant HER2 expression suppression, cell proliferation inhibition, and superior photothermal ablation. In a HER2+ breast tumor mouse model, the remarkable capability of the SERS surgical strategy for complete removal of HER2+ breast tumors through SERS‐guided surgical resection and intraoperative real‐time photothermal elimination is demonstrated. The results show complete eradiation of HER2+ breast tumors without local recurrence, consequently delivering a 100% tumor‐free survival. Expectedly, this SERS surgical strategy holds great promise for clinical treatment of HER2+ breast cancer with improved patients’ survival.
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