电流(流体)
医学
环境污染
肾脏疾病
环境规划
环境卫生
重症监护医学
环境科学
环境保护
工程类
内科学
电气工程
作者
Xiang Qian Lao,Yacong Bo,Dezhong Chen,Kai Zhang,Cheuk‐Chun Szeto
标识
DOI:10.1016/j.kint.2024.04.021
摘要
Environmental pollution significantly impacts global disease burden. However, the contribution of environmental pollution to kidney disease is often overlooked in nephrology. This review examines the growing body of research demonstrating the significant impacts of environmental pollutants, with a focus on air pollution as a primary factor, and acknowledges the roles of other pollutants, such as heavy metals, in the development and progression of kidney diseases. Short-term exposure to air pollution is linked with an increased risk of kidney disease-related events, including hospital admissions, and death, predominantly occurring in vulnerable populations. In contrast, long-term exposure, even at low to moderate levels, may lead to progressive pathophysiological changes, such as chronic systemic inflammation and oxidative stress, that contribute to the development of kidney disease. Additionally, air pollution may exacerbate traditional kidney disease risk factors such as hypertension and diabetes, thereby accelerating disease progression. The review also explores how climate change may interact with various pollutants, including air pollution, influencing kidney disease indirectly. The examined evidence underscores the urgent need for an interdisciplinary approach to research further into environmental kidney disease. Environmental health policies could play a crucial role in prevention, intervention, and the improvement of kidney health worldwide.
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