铜绿假单胞菌
免疫系统
主机响应
寄主(生物学)
肺
免疫学
疾病
医学
微生物学
生物
细菌
病理
内科学
生态学
遗传学
作者
Rhea Nickerson,Christina S. Thorton,Brent Johnston,Amy Huei‐Yi Lee,Zhenyu Cheng
标识
DOI:10.3389/fimmu.2024.1405376
摘要
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of exploiting barriers and immune defects to cause chronic lung infections in conditions such as cystic fibrosis. In these contexts, host immune responses are ineffective at clearing persistent bacterial infection, instead driving a cycle of inflammatory lung damage. This review outlines key components of the host immune response to chronic P. aeruginosa infection within the lung, beginning with initial pathogen recognition, followed by a robust yet maladaptive innate immune response, and an ineffective adaptive immune response that propagates lung damage while permitting bacterial persistence. Untangling the interplay between host immunity and chronic P. aeruginosa infection will allow for the development and refinement of strategies to modulate immune-associated lung damage and potentiate the immune system to combat chronic infection more effectively.
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