The present investigation aims to study the influence of thermal radiation and chemical reaction on the unsteady magnetized flow of Casson fluid with immersed nanoparticles. The flow is past a permeable stretching surface. The nanofluid heat transmission characteristics are described with the Buongiorno model. The governing system of non-linear partial differential equations (PDEs) is converted into non-linear ordinary differential equations (ODEs) with a similarity group of transformations. The reduced ODEs are numerically solved with an effective shooting strategy along with the standard R-K fourth-order method. The graphical illustration for the immerging parameters on non-dimensional velocity, temperature, and concentration is obtained through bvp4c using MATLAB. The code validation is provided by comparing the numerical outcomes of a few parameters with recently published work. The result shows that the thermal radiation boosts the energy supply in the flow field, and hence, the thermal regime enhances quickly. Due to the rise in chemical activity and Schmidt number, the concentration profile declines. The flow velocity declines with higher magnetic flux.