Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement

海马结构 神经科学 皮质酮 萎缩 树突棘 海马体 心理学 神经突 莫里斯水上航行任务 枝晶(数学) 内科学 医学 化学 激素 生物化学 体外 数学 几何学
作者
Nuno Sousa,Nikolay Lukoyanov,M. Dulce Madeira,Osborne F. X. Almeida,M. M. Paula‐Barbosa
出处
期刊:Neuroscience [Elsevier BV]
卷期号:97 (2): 253-266 被引量:704
标识
DOI:10.1016/s0306-4522(00)00050-6
摘要

We recently demonstrated that stress-induced cognitive deficits in rats do not correlate with hippocampal neuronal loss. Working on the premise that subtle structural changes may however be involved, we here evaluated the effects of chronic stress on hippocampal dendrite morphology, the volume of the mossy fiber system, and number and morphology of synapses between mossy fibers and CA3 dendritic excrescences. To better understand the mechanisms by which stress exerts its structural effects, we also studied these parameters in rats given exogenous corticosterone. Further, to search for signs of structural reorganization following the termination of the stress and corticosterone treatments, we analysed groups of rats returned to treatment-free conditions. All animals were assessed for spatial learning and memory performance in the Morris water maze. Consistent with previous findings, dendritic atrophy was observed in the CA3 hippocampal region of chronically stressed and corticosterone-treated rats; in addition, we observed atrophy in granule and CA1 pyramidal cells following these treatments. Additionally, profound changes in the morphology of the mossy fiber terminals and significant loss of synapses were detected in both conditions. These alterations were partially reversible following rehabilitation from stress or corticosterone treatments. The fine structural changes, which resulted from prolonged hypercortisolism, were accompanied by impairments in spatial learning and memory; the latter were undetectable following rehabilitation. We conclude that there is an intimate relationship between corticosteroid levels, hippocampal neuritic structure and hippocampal-dependent learning and memory.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小巧书雪完成签到,获得积分10
2秒前
大大怪将军完成签到,获得积分10
3秒前
哈哈哈完成签到 ,获得积分0
3秒前
小怪完成签到,获得积分10
4秒前
爱吃泡芙完成签到,获得积分10
5秒前
白桃战士完成签到,获得积分10
6秒前
8秒前
qingchenwuhou完成签到 ,获得积分10
8秒前
XXX完成签到,获得积分10
9秒前
锡嘻完成签到 ,获得积分10
9秒前
10秒前
彗星入梦完成签到 ,获得积分10
10秒前
恋恋青葡萄完成签到,获得积分10
10秒前
隐形万言完成签到,获得积分10
12秒前
Time完成签到,获得积分10
12秒前
土木研学僧完成签到,获得积分10
13秒前
yjy完成签到 ,获得积分10
13秒前
A溶大美噶完成签到,获得积分10
13秒前
yar应助萨尔莫斯采纳,获得10
14秒前
Will发布了新的文献求助10
14秒前
美好的鹏笑完成签到,获得积分10
16秒前
啦啦啦啦啦完成签到,获得积分10
16秒前
LYegoist完成签到,获得积分10
18秒前
可爱的小丸子完成签到,获得积分10
18秒前
一川烟叶完成签到,获得积分10
20秒前
20秒前
23秒前
iFan完成签到 ,获得积分10
23秒前
萨尔莫斯完成签到,获得积分10
23秒前
合适靖儿完成签到 ,获得积分10
25秒前
林林林完成签到,获得积分10
26秒前
斯琪欣完成签到,获得积分10
27秒前
28秒前
MQQ完成签到 ,获得积分10
28秒前
meng发布了新的文献求助10
28秒前
29秒前
zxc167完成签到,获得积分10
29秒前
研友_nVWP2Z完成签到 ,获得积分10
31秒前
俭朴的半雪完成签到 ,获得积分10
32秒前
大橙子发布了新的文献求助10
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022