Neurologic Toxicity Associated with High-Dose Metronidazole Therapy

Brief Reports1 March 1978Neurologic Toxicity Associated with High-Dose Metronidazole TherapySTEPHEN FRYTAK, M.D., CHARLES G. MOERTEL, M.D., F.A.C.P., DONALD S. CHILDS, M.D., JAMES W. ALBERS, M.D., Ph.D.STEPHEN FRYTAK, M.D., CHARLES G. MOERTEL, M.D., F.A.C.P., DONALD S. CHILDS, M.D., JAMES W. ALBERS, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-361 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpecial interest in hypoxic-cell radiation sensitizers and their potential application in the treatment of malignant tumors has been stimulated by the report of Urtasun and associates (1) on their experience in patients with highly anaplastic astrocytomas. The authors found a significant improvement in survival for patients treated with a combination of metronidazole and radiation therapy compared to patients treated with radiation therapy alone. Toxicity of the high-dose metronidazole therapy used in this and earlier studies by Urtasun and colleagues (2) was limited to anorexia, nausea, and vomiting. These findings could encourage a more widespread use of high-dose metronidazole as a...References1. URTASUNBANDCHAPMANFELDSTEINMIELKEFRYER RPJMBC: Radiation and high-dose metronidazole in supratentorial glioblastomas. N Engl J Med 294:1364-1367, 1976 CrossrefMedlineGoogle Scholar2. URTASUNCHAPMANBANDRABINSTURMWIND RJPHJ: Phase I study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. Radiology 117:129-133, 1975 CrossrefMedlineGoogle Scholar3. MIDHAMCGILVERAYCOOPER KIJ: Determination of therapeutic levels of metronidazole in plasma by gas-liquid chromatography. J Chromotogr 87:491-497, 1973 CrossrefMedlineGoogle Scholar4. SCHÄRER K: [Selective injury to Purkinje cells in the dog after oral administration of high-dose of nitroimidazole derivatives.] (Ger.) Verh Dtsch Ges Pathol 56:407-410, 1972 MedlineGoogle Scholar5. PLACIDIMASUOKAALCARAZTAYLOREARLE GDAJR: Distribution and metabolism of 14C-metronidazole in mice. Arch Int Pharmacodyn Ther 188:168-179, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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KUSUMI, M.D., JOSEPH F. PLOUFFE, M.D., ROBERT H. WYATT, M.D., ROBERT J. FASS, M.D.Update: Adolescent GynecologyAntiprotozoal drugsNeurological Complications of Hematopoietic Stem Cell Transplantation 1 March 1978Volume 88, Issue 3Page: 361-362KeywordsAstrocytomaCancer treatmentMalignant tumorsNauseaRadiation therapyToxicityVomiting Issue Published: 1 March 1978 PDF downloadLoading ...