Peripheral and central components of habituation of heat pain perception and evoked potentials in humans

习惯化 伤害 弥漫性有害抑制控制 神经科学 刺激(心理学) 有害刺激 刺激 伤害感受器 心理学 总和 医学 听力学 化学 麻醉 内科学 认知心理学 受体
作者
Wolfgang Greffrath,Ulf Baumgärtner,Rolf‐Detlef Treede
出处
期刊:Pain [Lippincott Williams & Wilkins]
卷期号:132 (3): 301-311 被引量:219
标识
DOI:10.1016/j.pain.2007.04.026
摘要

For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
Rondab应助飘逸曼彤采纳,获得30
1秒前
香蕉觅云应助Lam采纳,获得10
3秒前
李健应助malele采纳,获得10
3秒前
dddd发布了新的文献求助10
3秒前
呛呛完成签到,获得积分20
4秒前
4秒前
所所应助大成子采纳,获得10
4秒前
yyy发布了新的文献求助30
4秒前
PF发布了新的文献求助10
5秒前
呛呛发布了新的文献求助30
8秒前
10秒前
bkagyin应助水流众生采纳,获得10
11秒前
11秒前
11秒前
1203完成签到,获得积分10
11秒前
藤藤完成签到,获得积分10
11秒前
shawn完成签到,获得积分10
12秒前
认真的向卉完成签到,获得积分10
13秒前
13秒前
13秒前
打打应助cc采纳,获得10
13秒前
13秒前
沉静安荷发布了新的文献求助10
14秒前
小二郎应助游侠小林采纳,获得10
14秒前
14秒前
呼呼哈哈完成签到,获得积分10
15秒前
cc0514gr完成签到,获得积分10
15秒前
16秒前
大成子发布了新的文献求助10
16秒前
周星星发布了新的文献求助10
17秒前
feedyoursoul发布了新的文献求助10
18秒前
19秒前
PATTOM完成签到,获得积分10
19秒前
19秒前
Margaery完成签到,获得积分10
19秒前
烊烊发布了新的文献求助10
19秒前
19秒前
CodeCraft应助如意枫叶采纳,获得10
19秒前
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989469
求助须知:如何正确求助?哪些是违规求助? 3531722
关于积分的说明 11254409
捐赠科研通 3270221
什么是DOI,文献DOI怎么找? 1804946
邀请新用户注册赠送积分活动 882113
科研通“疑难数据库(出版商)”最低求助积分说明 809176