坏死性下垂
化学
程序性细胞死亡
半胱氨酸蛋白酶
细胞凋亡
机制(生物学)
细胞生物学
立体化学
生物化学
生物
认识论
哲学
作者
Ke Wang,Jinfeng Li,Alexei Degterev,Emily Hsu,Junying Yuan,Chengye Yuan
标识
DOI:10.1016/j.bmcl.2006.11.056
摘要
Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure–activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.
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