巨噬细胞
表型
促炎细胞因子
体内
生物
免疫学
肺泡巨噬细胞
病毒
功能(生物学)
甲型流感病毒
炎症
体外
细胞生物学
基因
遗传学
作者
Marlynne Q. Nicol,Bernadette M. Dutia
出处
期刊:Future Virology
[Future Medicine]
日期:2014-09-01
卷期号:9 (9): 847-862
被引量:33
摘要
The importance of macrophages in the control of infections has long been documented, but macrophages have also been shown to contribute to severe influenza A virus infections. Macrophage function ranges from highly proinflammatory to wound healing and regulatory and a picture of diverse subsets with considerable plasticity in function and phenotype is emerging. Within the lung three subsets of macrophage populations have been identified: resident alveolar macrophages, interstitial macrophages and exudate-derived macrophages. Here we review model systems and techniques for defining macrophage function in vivo and discuss macrophage infection in vitro. The use of detailed phenotypic approaches and techniques to dissect the role of individual macrophage subsets in vivo promises rapid advances in this area of research.
科研通智能强力驱动
Strongly Powered by AbleSci AI