Ultrastructural Immunolocalization of α-Elastin and Keratan Sulfate Proteoglycan in Normal and Scoliotic Lumbar Disc

KS proteoglycans and elastic fibers are closely associated with the lamellar organization of the collagen fibers in a normal disc. In scoliosis, impaired regulation of collagen fibrillogenesis by lumican or fibromodulin may result in disruption of the lamellar structure.