亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study

医学 握力 慢性阻塞性肺病 流行病学 心肌梗塞 前瞻性队列研究 物理疗法 混淆 冲程(发动机) 手部力量 人口 内科学 急诊医学 环境卫生 机械工程 工程类
作者
Darryl P. Leong,Koon Teo,Sumathy Rangarajan,Patricio López‐Jaramillo,Álvaro Avezum,Andrés Orlandini,Pamela Serón,Suad Hashim Ahmed,Annika Rosengren,Roya Kelishadi,Omar Rahman,Sumathi Swaminathan,Romaina Iqbal,Rajeev Gupta,Scott A. Lear,Aytekin Oğuz,Khalid Yusoff,Katarzyna Zatońska,Jephat Chifamba,Ehimario Igumbor,Viswanathan Mohan,Ranjit Mohan Anjana,Hongqiu Gu,Wei Li,Salim Yusuf
出处
期刊:The Lancet [Elsevier]
卷期号:386 (9990): 266-273 被引量:1530
标识
DOI:10.1016/s0140-6736(14)62000-6
摘要

Background Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries. Methods The Prospective Urban-Rural Epidemiology (PURE) study is a large, longitudinal population study done in 17 countries of varying incomes and sociocultural settings. We enrolled an unbiased sample of households, which were eligible if at least one household member was aged 35–70 years and if household members intended to stay at that address for another 4 years. Participants were assessed for grip strength, measured using a Jamar dynamometer. During a median follow-up of 4·0 years (IQR 2·9–5·1), we assessed all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, myocardial infarction, stroke, diabetes, cancer, pneumonia, hospital admission for pneumonia or chronic obstructive pulmonary disease (COPD), hospital admission for any respiratory disease (including COPD, asthma, tuberculosis, and pneumonia), injury due to fall, and fracture. Study outcomes were adjudicated using source documents by a local investigator, and a subset were adjudicated centrally. Findings Between January, 2003, and December, 2009, a total of 142 861 participants were enrolled in the PURE study, of whom 139 691 with known vital status were included in the analysis. During a median follow-up of 4·0 years (IQR 2·9–5·1), 3379 (2%) of 139 691 participants died. After adjustment, the association between grip strength and each outcome, with the exceptions of cancer and hospital admission due to respiratory illness, was similar across country-income strata. Grip strength was inversely associated with all-cause mortality (hazard ratio per 5 kg reduction in grip strength 1·16, 95% CI 1·13–1·20; p<0·0001), cardiovascular mortality (1·17, 1·11–1·24; p<0·0001), non-cardiovascular mortality (1·17, 1·12–1·21; p<0·0001), myocardial infarction (1·07, 1·02–1·11; p=0·002), and stroke (1·09, 1·05–1·15; p<0·0001). Grip strength was a stronger predictor of all-cause and cardiovascular mortality than systolic blood pressure. We found no significant association between grip strength and incident diabetes, risk of hospital admission for pneumonia or COPD, injury from fall, or fracture. In high-income countries, the risk of cancer and grip strength were positively associated (0·916, 0·880–0·953; p<0·0001), but this association was not found in middle-income and low-income countries. Interpretation This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease. Further research is needed to identify determinants of muscular strength and to test whether improvement in strength reduces mortality and cardiovascular disease. Funding Full funding sources listed at end of paper (see Acknowledgments).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
天天快乐应助温暖砖头采纳,获得10
2秒前
d00007发布了新的文献求助10
2秒前
6秒前
斯文败类应助面包呀采纳,获得10
9秒前
间质发布了新的文献求助10
9秒前
zj发布了新的文献求助10
10秒前
16秒前
23秒前
27秒前
淡淡十三完成签到,获得积分10
28秒前
SYX完成签到 ,获得积分10
35秒前
香蕉觅云应助xuan采纳,获得10
40秒前
45秒前
Yz完成签到 ,获得积分10
47秒前
xuan发布了新的文献求助10
50秒前
青树柠檬完成签到 ,获得积分10
51秒前
53秒前
bkagyin应助科研通管家采纳,获得10
54秒前
情怀应助科研通管家采纳,获得10
54秒前
科研通AI2S应助科研通管家采纳,获得10
54秒前
深情安青应助科研通管家采纳,获得10
54秒前
温暖砖头发布了新的文献求助10
58秒前
Chris完成签到 ,获得积分0
1分钟前
打打应助漱泉枕石采纳,获得10
1分钟前
1分钟前
漱泉枕石发布了新的文献求助10
1分钟前
健壮紊发布了新的文献求助20
1分钟前
1分钟前
旺仔完成签到,获得积分10
1分钟前
旺仔发布了新的文献求助10
1分钟前
NIGANSHA完成签到 ,获得积分10
2分钟前
2分钟前
Raine完成签到,获得积分10
2分钟前
橙橙完成签到,获得积分10
2分钟前
2分钟前
2分钟前
间质发布了新的文献求助10
2分钟前
托丽莲睡拿完成签到,获得积分10
2分钟前
2分钟前
xujiejiuxi发布了新的文献求助30
2分钟前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
Shining Light on the Dark Side of Personality 400
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3307345
求助须知:如何正确求助?哪些是违规求助? 2941006
关于积分的说明 8500094
捐赠科研通 2615318
什么是DOI,文献DOI怎么找? 1428830
科研通“疑难数据库(出版商)”最低求助积分说明 663581
邀请新用户注册赠送积分活动 648410