Efficient Analysis of Experimental Observations

The prime goal of this chapter is to encourage researchers in pharmacology to make use of some of the statistical techniques developed in recent years that could increase the efficiency of their analyses. The topics we have chosen to illustrate are fractional replicates of fac­ torial experiments, single degrees of freedom and half-normal plots in the analysis of variance, robust estimation, and up-and-down method for quan­ tal responses. Briefly, the advantages of the techniques illustrated here are the follow­ ing.