前额叶皮质
眶额皮质
扁桃形结构
心理学
冲动性
神经科学
预测(人工智能)
消费者神经科学
断开
基底外侧杏仁核
延迟贴现
前额叶腹外侧皮质
伏隔核
背外侧前额叶皮质
中枢神经系统
发展心理学
认知
法学
人工智能
计算机科学
政治学
作者
John C. Churchwell,Andrea M. Morris,Nila M. Heurtelou,Raymond P. Kesner
摘要
Interactions between the prefrontal cortex and amygdala are thought to be critical for reward anticipation. Alterations in reward anticipation that lead to an inability to wait for rewards or a diminished capacity to change behavior when doing so would be optimal are often termed impulsivity and compulsivity, respectively. Distinct regions of the prefrontal cortex may support decreased impulsivity through self-control and decreased compulsivity through flexibility. However, both self-control and flexibility appear to involve the amygdala. Using a delay discounting paradigm, the current investigation found that inactivation and disconnection of the medial prefrontal cortex and basolateral amygdala led rats to become more impulsive by affecting preference for smaller immediate over larger delayed rewards. Conversely, inactivation and disconnection of the orbitofrontal cortex and amygdala led rats to become more compulsive as demonstrated by an inability to flexibly reverse stimulus-reward relationships in an odor reversal task. The current findings support a double dissociation between orbitofrontal cortex-amygdala interactions for odor reversal and medial prefrontal cortex-amygdala interactions for delay discounting.
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