TLR7型
TLR9型
类胡萝卜素
核酸
模式识别受体
生物
背景(考古学)
免疫学
干扰素
先天免疫系统
免疫系统
细胞内
浆细胞样树突状细胞
角质形成细胞
Toll样受体
伤口愈合
受体
细胞生物学
树突状细胞
体外
基因表达
生物化学
基因
DNA甲基化
古生物学
作者
Josh Gregorio,Stephan Meller,Curdin Conrad,Anna Di Nardo,Bernhard Homey,Antti Lauerma,Naoko Arai,Richard L. Gallo,John DiGiovanni,Michel Gilliet
摘要
Plasmacytoid dendritic cells (pDCs) are specialized type I interferon (IFN-α/β)-producing cells that express intracellular toll-like receptor (TLR) 7 and TLR9 and recognize viral nucleic acids in the context of infections. We show that pDCs also have the ability to sense host-derived nucleic acids released in common skin wounds. pDCs were found to rapidly infiltrate both murine and human skin wounds and to transiently produce type I IFNs via TLR7- and TLR9-dependent recognition of nucleic acids. This process was critical for the induction of early inflammatory responses and reepithelization of injured skin. Cathelicidin peptides, which facilitate immune recognition of released nucleic acids by promoting their access to intracellular TLR compartments, were rapidly induced in skin wounds and were sufficient but not necessary to stimulate pDC activation and type I IFN production. These data uncover a new role of pDCs in sensing tissue damage and promoting wound repair at skin surfaces.
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