受体
品味
味觉感受器
GPR120
G蛋白偶联受体
苦味
生物化学
生物
化学
作者
Wolfgang Meyerhof,Claudia Batram,Christina Kühn,Anne Brockhoff,Elke Chudoba,Bernd Bufe,Giovanni Appendino,Maik Behrens
出处
期刊:Chemical Senses
[Oxford University Press]
日期:2009-12-18
卷期号:35 (2): 157-170
被引量:983
标识
DOI:10.1093/chemse/bjp092
摘要
Humans perceive thousands of compounds as bitter. In sharp contrast, only ∼25 taste 2 receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how the vast array of bitter compounds can be detected by such a limited number of sensors. To address this issue, we have challenged 25 human taste 2 receptors (hTAS2Rs) with 104 natural or synthetic bitter chemicals in a heterologous expression system. Thirteen cognate bitter compounds for 5 orphan receptors and 64 new compounds for previously identified receptors were discovered. Whereas some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness. Thus, 3 hTAS2Rs together were able to detect ∼50% of the substances used. Conversely, though 63 bitter substances activated only 1–3 receptors, 19 compounds stimulated up to 15 hTAS2Rs. Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs.
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