废止
对映选择合成
化学
迈克尔反应
对映体
加合物
结合
羟醛反应
衍生工具(金融)
立体化学
有机化学
组合化学
催化作用
数学
业务
数学分析
财务
作者
Florian Gallier,Arnaud Martel,Gilles Dujardin
标识
DOI:10.1002/anie.201701401
摘要
The Robinson annulation is a reaction that has been useful for numerous syntheses since its discovery in 1935, especially in the field of steroid synthesis. The products are usually obtained after three consecutive steps: the formation of an enolate (or derivative), a conjugate addition, and an aldol reaction. Over the years, several methodological improvements have been made for each individual step or alternative routes have been devised to access the Robinson annulation products. The first part of this Review outlines the most relevant developments towards the formation of monocarbonyl-derived Robinson annulation products (MRA products, MRAPs) and activated monocarbonyl-derived Robinson annulation products (AMRA products, AMRAPs). The following sections are then devoted to the diastereoselective and enantioselective synthesis of these products, while the last section describes the enantiomeric resolution of racemic mixtures.
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