Descending monoaminergic pain modulation: Bidirectional control and clinical relevance

GLOSSARY: CGRP = calcitonin gene-related peptide; DAT = dopamine transporter; GABA = γ-aminobutyric acid; NET = norepinephrine transporter; NRM = nucleus raphe magnus; PAG = periaqueductal gray; RLS = restless legs syndrome; RVMM = rostral ventromedial medulla; SERT = serotonin transporter; SNRI = serotonin and norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor; STT = spinothalamic tract.